Halogen Bonding Based Recognition Processes: A World Parallel to Hydrogen Bonding
Acc. Chem. Res. 2005, 38, 386
P. Metrangolo, H. Neukirch, T. Pilati, G. Resnati
Binding of a trichloro substituted inhibitor of the human Xa factor of the human blood coagulation cascade and the receptorial pocket of the Xa factor with O...Cl and S...Cl short contacts.
Binding of a trichloro substituted inhibitor of the human Xa factor of the human blood coagulation cascade and the receptorial pocket of the Xa factor with O...Cl and S...Cl short contacts.
ABSTRACT
Halogen bonding is the noncovalent interaction between halogen atoms (Lewis acids) and neutral or anionic Lewis bases. The main features of the interaction are given, and the close similarity with the hydrogen bonding will become apparent. The potential of the interaction is shown by useful applications in the fields of synthetic chemistry, material science, and bioorganic chemistry.